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AMP-activated protein kinase. 5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low.
13 mar 2019 · AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis that is activated by physiological regulators associated with health and longevity.
1 kwi 2016 · AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand.
31 paź 2022 · The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP ratios. Once...
Modulation of the transcription of autophagy and lysosome genes by AMPK. AMP-activated protein kinase (AMPK) regulates the activity of forkhead box protein O3 (FOXO3) through direct phosphorylation.
9 lis 2018 · Here we provide an overview of AMPK structures, and how these structures, in combination with biochemical, biophysical, and mutational analyses provide insights into the mechanisms of adenine nucleotide binding and AMPK activity modulation.
As a hub of lipid metabolism and processing, AMPK has identified actions on key components of lipid homeostasis at the ER, including sterol regulatory-element binding protein 1c (SREBP-1c) and 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR). AMPK phosphorylates SREBP-1c directly.
