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31 mar 2023 · Taking high doses of folic acid supplements may cause side effects, including accelerating mental decline in older adults and increasing the likelihood of cancer recurring. Folic acid is the...
12 paź 2016 · High folic acid intakes have been linked to increased cancer risk and progression within certain patient groups and also to insulin resistance in children, interaction with epilepsy medications...
6 lis 2023 · The prevailing theory is that excess folic acid can disrupt the balance of SAM and its demethylated product, namely, S-adenosylhomocysteine (SAH). This disruption could lead to global DNA hypomethylation, resulting in genomic instability, altered gene expression, and an increased risk of diseases.
6 lis 2023 · This review delves into the intricate relationship between excess folate (vitamin B9) intake, especially its synthetic form, namely, folic acid, and its implications on health and disease.
Deficiency of folate is common, with studies suggesting prevalence of deficiencyas high as 85.5% as was shown in women between the ages of 16 and 49, living in the UK. Causes of folate deficiency range from diet and lifestyle, to pathological and pharmacological processes.
The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid.
13 lis 2023 · It is unlikely that the ULs for supplemental folate are exceeded in European populations, except for regular users of food supplements containing high doses of folic acid/5‐methyl‐tetrahydrofolic acid salts.
