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1 kwi 2023 · Protein science is being transformed by powerful computational methods for structure prediction and design: AlphaFold2 can predict many natural protein structures from sequence, and other AI methods are enabling the de novo design of new structures.
Here, we review recent progress in the folding, unfolding and refolding of α-helical membrane proteins and compare the molecular interactions that stabilise proteins in lipid bilayers.
1 wrz 2023 · Alpha-1 antitrypsin abnormality leads to protein folding disorder. It causes insoluble aggregates in hepatocytes, leading to hepatocellular cancer and cirrhosis of the liver (Mitchell and Khan, 2017).
1 paź 2018 · General features of alpha-helical membrane protein folding are reviewed. Helix fraying can provide interfacial stabilization and modulation of dynamics. Membrane peptide topology may be pH-dependent. Some peptides are able to passively cross lipid bilayers.
Protein science is being transformed by powerful computational methods for structure prediction and design: AlphaFold2 can predict many natural protein structures from sequence, and other AI methods are enabling the de novo design of new structures.
2 lut 2022 · Altering the lipids in the bilayer is known to affect the probability of transmembrane helix insertion into the membrane, and lipids also affect protein stability and can promote successful folding.
18 wrz 2017 · Pressing puzzles such as why certain sequences of helix-breakers and helix-formers may adopt an all-α fold in one environment, all-β fold in another, and collapse into a coil in yet another one, are bound to remain elusive unless these questions are answered.
