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2,3,7,8-Tetrachlorodibenzodioksyna, TCDD – organiczny związek chemiczny z grupy dioksyn o bardzo dużej toksyczności. Związek ten został prawdopodobnie wykorzystany do usiłowania otrucia Wiktora Juszczenki jesienią 2004 roku w czasie kampanii prezydenckiej na Ukrainie.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a polychlorinated dibenzo-p-dioxin (sometimes shortened, though inaccurately, to simply 'dioxin') with the chemical formula C 12 H 4 Cl 4 O 2. Pure TCDD is a colorless solid with no distinguishable odor at room temperature.
Toxic equivalency factor (TEF) expresses the toxicity of dioxins, furans and PCBs in terms of the most toxic form of dioxin, 2,3,7,8-TCDD. The toxicity of the individual congeners may vary by orders of magnitude.
5 cze 2024 · Toxicity Equivalence (TEQ). For a single DLC, dioxin toxicity equivalence (or TCDD TEQ) is the product of the concentration of the DLC in an environmental mixture and its corresponding TEF; total TEQ for the mixture is the sum of the individual TCDD TEQs across the DLCs.
Carcinogenicity studies with several strains of rats, mice and Syrian hamsters treated with 2,3,7,8-tetrachlorodibenzo- para -dioxin (TCDD) via the oral route (gavage or diet), by intra-peritoneal injection, or by skin application have been reviewed in IARC Monograph Volume 69 ( IARC, 1997 ).
20 lut 2024 · EPA will use this reported mass quantity data to calculate toxic equivalency (TEQ) values. TEQs are a weighted quantity measure based on the toxicity of each member of the dioxin and dioxin-like compounds category relative to the most toxic members of the category.
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and DLCs are structurally and toxicologically related halogenated aromatic hydrocarbons. The EPA recommends that the toxicity equivalence factor (TEF) methodology, a component mixture method, be used to evaluate human health risks posed by these mixtures, using TCDD as the index chemical.
