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The Topo I-like pattern can comprise staining of five subcellular regions: 1) Prominent fine speckled nuclear staining in interphase cells. 2) Consistent strong fine speckled staining of condensed chromatin in mitotic cells.
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5 sty 2022 · Second, the nuclear dense fine-speckled (AC-2) and Topo I-like (AC-29) patterns are realigned closer to the nuclear homogeneous pattern (AC-1) to highlight their similarities in staining of both interphase nuclei and mitotic condensed chromatin.
The speckled pattern in ANA (Antinuclear Antibody) testing is one of the most common and diagnostically significant patterns, characterized by its distinctive, fine or coarse speckled appearance under a fluorescence microscope.
19 maj 2015 · 1) Prominent fine speckled AC-4 type nuclear staining in interphase cells. 2) Consistent strong fine speckled staining of condensed chromatin in mitotic cells. Depending on the serum dilution used, the mitotic chromatin staining may appear homogeneous.
17 sty 2019 · Scleroderma or systemic sclerosis: ANA pattern is most commonly speckled, followed by centromeric and less commonly nucleolar. Mixed connective tissue disease: ANA pattern is almost always ...
5 sty 2022 · The International Consensus on ANA Patterns (ICAP) classifies 30 relevant patterns (AC-0 to AC-29). AC-4 (fine speckled nuclear pattern) is associated to anti-SS-A/Ro, anti-SS-B/La, and several...
23 lis 2020 · The competent-level patterns centromere (AC-3), homogeneous (AC-1), speckled (AC-2,4,5) and nucleolar (AC-8,9,10) patterns were used in ANA IIF test result reporting by > 90% of competent-level and expert-level laboratories (Table 2). The nuclear dot patterns (AC-6,7) were reported by 85% of the laboratories and the DFS pattern (AC-2) by 62% of ...
